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Risk Factors for Breast Cancer - Genetics + Lifestyle

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Genetics and lifestyle affect your breast cancer risk

The statistics are bone chilling – one out of every eight women will be diagnosed with breast cancer in their lifetimes. When a health threat is this pervasive, it is clearly in the best interests of every woman to take all possible precautions to protect herself and reduce her risk of being stricken with this potentially deadly disease.

But what exactly are the risk factors for breast cancer? It is vitally important that all women know the answer to this question, so they are able to make aware and informed decisions about how exactly they are going to protect themselves when those risks are present.

Genetic Risk Factors
Of course there is nothing anyone can do to eliminate a genetic predisposition to a disease. Since early detection of breast cancer dramatically increases the odds of survival, however, women who know they may be at greater risk of developing this disease can protect themselves by getting precautionary mammograms more frequently.

The genetic factors for breast cancer that have been discovered so far include:

  • Age – only one out of eight breast cancer victims are under 45, while two-thirds are over 55
  • Genetic mutation – mutations in the BRCA 1 and 2 genes disable breast cancer defenses, and 80% of those who have such a mutation will eventually develop the disease
  • Family history – any women whose mother, daughter or sister had the disease faces double the normal risk of having breast cancer and triple the risk if two close family members have had it
  • More dense breast tissue – more glandular tissue and less fatty tissue elevates the risk
  • Menstrual periods – if periods began before 12 or menopause occurred after 55 the risk of developing the disease is higher
  • Benign breast lesions – when breasts have shown a predisposition for abnormal cell growth, the likelihood of cancer eventually developing increases five fold
  • Past radiation exposure – past radiation treatment for cancer or another disease in the chest area increases breast cancer risk, if the earlier exposure occurred before the age of 40
  • Race and ethnicity – white women are slightly more vulnerable than the female population as a whole, while African-American women are more likely to die from the disease. Late detection plays a role in the morbidity and mortality outcomes of African-Americans women.
  • Past incidence – anyone who has been diagnosed with breast cancer in the past is up to four times more likely to get it again

Risk Factors Based on Lifestyle
Certain risk factors are related to lifestyle choices. In some instances, activities that increase breast cancer risk may have other benefits, so individual women will have to decide for themselves how to weigh the dangers against the potential rewards with respect to these breast cancer risk factors:

  • Age of childbirth and breastfeeding – fewer lifetime menstrual cycles reduce exposure to estrogen and progesterone (and vice versa). These female hormones are involved in reproduction and implicated in breast cancer development. This is the likely explanation for why women who postpone childbirth until after the age of 30 face greater breast cancer risk, while breast-feeding at any age appears to reduce the risk somewhat.
  • Hormone replacement therapy after menopause – these therapies can be quite helpful in reducing the symptoms of menopause, but they can raise the risk of breast cancer by increasing the amount of exposure to estrogen and progesterone. It is combination hormone therapy, which uses both of these, that has been implicated in greater incidence of breast cancer, along with estrogen therapy alone if continued for more than ten years.
  • Obesity – fat tissue actually releases estrogen, and it has been found that in obese women who have already undergone menopause the risk of breast cancer developing is increased
  • Alcohol – there is a linear relationship between the amount of alcohol consumed and the increase in the incidence of breast cancer, so moderation is encouraged
  • Birth control pills – taking them can increase the risk of breast cancer slightly
  • Smoking – for a long time this was in dispute. However, a March 2011 study published in the British Medical Journal involving 79,000 women found that in comparison to non-smokers, former smokers were 9% more likely to develop breast cancer, current smokers 16% more likely and women who smoked for over 50 years were 35% more likely.

Taking Control Over Breast Cancer
Women over the age of 40 should have a precautionary mammogram taken every year. However, if risk factors are present then this frequency should be increased and women under 40 should also receive regular mammograms if they are at higher than normal risk. Lifestyle adjustments may also be called for, if the risk factors present are something over which a woman has some control. These steps are highly recommended, as there is no question that a proactive approach can dramatically reduce the threat of breast cancer for the majority of women.

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