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The Value of the Preventative Mastectomy

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Are mastectomies to prevent breast cancer worth it?

Receiving a diagnosis of breast cancer changes a woman's life forever. No matter how early the cancer is caught, breast cancer brings a sense of uncertainty into a woman's life that will never completely go away. Even if aggressive treatment ultimately sends the cancer into remission, the fear that the cancer might some day come back is likely to become a pervasive presence in the life of a breast cancer survivor.

One of the ways that oncologists treat breast cancer is by performing a mastectomy, which involves the complete removal of a breast that has been compromised by breast cancer. Despite the emotional and physical toll that is exacted by undergoing such a radical procedure, mastectomies do sometimes bring a peace of mind to women who worry that other types of treatment may not be enough to truly eliminate all of the cancer. In fact, that sense of relief is so strong that some women choose to take things one step further and have both breasts removed, even though only one has been infected by cancer. Because breast cancer can eventually develop in a healthy breast even after it has been successfully treated in the other, these preventative mastectomies are a way that some women choose to maximize their sense of safety and relief.

But are preventative mastectomies really a wise or necessary strategy in the battle against breast cancer? According to a recently published exhaustive research study, the answer to that question is no.

Preventative Mastectomies on Trial
In 2010, the Journal of the National Cancer Institute published the results of a study carried out at the MD Anderson Cancer Center in Houston. This study looked at the case histories of 107,000 women who had undergone mastectomies, a number that included 8,900 women who had chosen to have both of their breasts removed to help reduce the chances of their cancer returning. Preventative mastectomies have become increasingly popular over the past several years; between 1998 and 2003 alone, double mastectomies in the US increased by 150%, and about 11% of the mastectomies that are now performed involve the removal of non-cancerous breasts. Because preventative mastectomies have become so common, researchers have naturally been interested in finding out if their widespread use is really justified, and that was the motivation for the study carried out at the Anderson Cancer Center.

The Anderson study focused primarily on the question of lifespan. Specifically, they wanted to find out if preventative mastectomies actually helped breast cancer victims live longer. As it turns out, this procedure is able to extend life span - but surprisingly, only in certain cases, and even then the positive effects are only modest.

Preventative Mastectomies: Failures and Successes
Survival benefits were found for women under the age of 50 with estrogen-receptor breast cancer in stage I or II. Among this group, five-year survivor rates were 4.8% higher for women who had undergone a double mastectomy instead of only having their cancerous breast removed. This is not a great benefit by any means; nevertheless, it did represent the first scientific proof ever obtained that showed a survival advantage for those women who had chosen to have a preventative mastectomy.

Unfortunately, the number of women who fit this breast cancer profile is under 10%. For women whose cancers did not fit in this category - the vast majority - having a preventative mastectomy performed did not extend life span at all. While no one would dispute that this procedure can reduce the chances of breast cancer recurrence, in most cases cancers that recur are caught in the early stages, when they are more easily curable, because those who have had breast cancer in the past are always being closely monitored. With estrogen-receptor positive cancers (a clear majority among breast cancers diagnosed), hormone therapy with drugs like tamoxifen can disrupt the process through which cancer cells grow and divide by cutting off their supply of life-giving estrogen. In postmenopausal women, aromatase inhibitors used in targeted therapy can help stop the effects of estrogen released by the body's fat cells.

Facing Mortality
The desire of women to feel secure and safe inside their own bodies is understandable. However, the value of preventative mastectomies for women who have had breast cancer diagnosed and hope to keep it from coming back in the future once it is in remission has not been validated by the survival statistics. Having a healthy part of the body preemptively removed can help keep cancer from recurring in some cases. But what makes breast cancer so frightening to those who contract it is the fact that it brings them face to face with their own mortality. From the standpoint of survival, we now know that preventative mastectomies only provide tangible benefits to a small subset of breast cancer victims. For the rest, removing healthy breasts in the name of prevention appears to be a medical strategy without any real merit.

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